NEW YORK -- Red Sox manager John Farrell boiled over with frustration on Sunday night after a replay call was challenged and overturned, leading to the Yankees scoring what ended up being the deciding run in the series finale. Farrell was ejected, as managers have been instructed not to argue plays under review.

The play happened in the bottom of the fourth inning, when Francisco Cervelli hit a grounder to third, with the Red Sox attempting a 5-4-3 double play.

Cervelli, who was injured on the play, was originally ruled out at first. But Yankees manager Joe Girardi challenged it, and the call was overturned.

Once it was overturned, Brian McCann's run that would have been erased if the inning had ended on the double play then counted. The Red Sox lost the game, 3-2.

"We felt that it was clear that the replay was inconclusive," said Farrell. "Any angle that we looked at, you couldn't tell if the foot was on the bag behind Mike Napoli's leg."

Part of Farrell's frustration stemmed from Saturday, when he challenged a call at second base on a double by Dean Anna. The call stood, only to have Major League Baseball say after the game that it should have been overturned.

"On the heels of yesterday, it's hard to have any faith in the system, to be honest with you," said Farrell.

Even though Farrell knew he can't argue replay calls, he felt this one left him no choice.

"I argued the point that it was inconclusive. I know that arguing a challenge play is not allowed, evident by spending most of the game inside," Farrell said. "But on the heels of yesterday and today, this is a tough pill to swallow. It's extremely difficult to have any faith in the system, the process that's being used."

Sunday's ejection was Farrell's first of the season.

"John is very disciplined, a very calm guy," said Red Sox slugger David Ortiz. "But when he feels like he's right, he'll let you know. That was a moment when he felt he was right about what he's complaining about. That's basically why he got hot. But hey, I think the video thing, we're going to get things better, definitely."