BALTIMORE -- Melvin Mora's two-run homer was ruled fan interference after umpires used instant replay during the first inning of the game between the Orioles and the Mariners on Tuesday.

Mora's deep fly ball to left field was initially ruled a home run by third-base umpire Fieldin Culbreth. The ruling sent Seattle manager Don Wakamatsu out of the dugout to dispute the call, and the umpires left the field to look at the replay. After the review, the ruling was changed to fan interference, resulting in the final out of the inning.

The home run would have given the Orioles a 3-0 lead, but with the ruling the score remained 1-0.

Seattle left fielder Eric Chavez attempted to catch the ball at the wall when a fan appeared to reach over and interfere. After the review, home-plate umpire Gary Cederstrom called both managers over to conference before signaling that the play had resulted in an out.

This was the first use of instant replay at Orioles Park at Camden Yards, and the second time it's been used this season in games between the two clubs. Instant replay was used on June 3 at Seattle, overturning an Aubrey Huff hit that, after review, was ruled to have gone into foul territory. That replay was the first in Orioles history and first in Safeco Field history.